Contributions of residual calcium to fast synaptic transmission.

  title={Contributions of residual calcium to fast synaptic transmission.},
  author={Chinfei Chen and Wade G Regehr},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={19 15},
Fast neurotransmitter release is driven by high calcium (10-100 microM) near open channels (Ca(local)), followed by a much smaller (<1 microM), longer-lasting residual calcium (Ca(res)). The most prominent component of release, phasic release, lasts several milliseconds and is thought to be triggered by Ca(local). A transient tail of release then continues over the next 20 msec at 1-10% of peak rates. This transient component of release, which we refer to as TR, is poorly understood, and there… CONTINUE READING


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