Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans.

@article{Lecavalier1989ContributionsOG,
  title={Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans.},
  author={L Lecavalier and Geremia B Bolli and Philip E. Cryer and John E. Gerich},
  journal={The American journal of physiology},
  year={1989},
  volume={256 6 Pt 1},
  pages={E844-51}
}
To estimate the relative contributions of gluconeogenesis and glycogenolysis to the increase in hepatic glucose output (HGO) during glucose counterregulation under conditions simulating clinical insulin hypoglycemia, we induced moderate hypoglycemia (approximately 55 mg/dl) with a continuous infusion of insulin that resulted in physiological hyperinsulinemia (approximately 20 microU/ml) in eight normal volunteers and estimated gluconeogenesis by two methods: an isotopic approach in which… CONTINUE READING

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