Contributions of four cortex lytic enzymes to germination of Bacillus anthracis spores.

@article{Heffron2010ContributionsOF,
  title={Contributions of four cortex lytic enzymes to germination of Bacillus anthracis spores.},
  author={Jared D. Heffron and Emily A. Lambert and Nora Sherry and David L Popham},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 3},
  pages={763-70}
}
Bacterial spores remain dormant and highly resistant to environmental stress until they germinate. Completion of germination requires the degradation of spore cortex peptidoglycan by germination-specific lytic enzymes (GSLEs). Bacillus anthracis has four GSLEs: CwlJ1, CwlJ2, SleB, and SleL. In this study, the cooperative action of all four GSLEs in vivo was investigated by combining in-frame deletion mutations to generate all possible double, triple, and quadruple GSLE mutant strains. Analyses… CONTINUE READING
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