Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2/H+.

  title={Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2/H+.},
  author={Hubert V. Forster and Curtis A. Smith},
  journal={Journal of applied physiology},
  volume={108 4},
The major objective of this review is to evaluate existing information and reach conclusions regarding whether there is interaction between P(CO(2))/H(+) stimulation of carotid (peripheral) and intracranial (central) chemoreceptors. Interaction is defined as a ventilatory response to simultaneous changes in the degree of Pco2/H(+) stimulation of both chemoreceptors that is greater (hyperadditive) or less (hypoadditive) than the sum of the responses when stimulation of each set of chemoreceptors… CONTINUE READING


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