Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation

@inproceedings{Cohen2012ContributionsOC,
  title={Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation},
  author={Jonathan M. Cohen and Suneeta Chimalapati and Corn{\'e} P. de Vogel and Alex van Belkum and Helen E. Baxendale and Jeremy S Brown},
  booktitle={Vaccine},
  year={2012}
}
Live attenuated vaccines have been proposed as a strategy to induce protective immunity against infectious diseases. Recent data have demonstrated that nasopharyngeal colonisation with Streptococcus pneumoniae induces protective immunity against subsequent invasive infection, suggesting nasal vaccination with live attenuated bacteria could be a preventative strategy. However the bacterial factors affecting the strength of this adaptive immune response remain unclear. In a direct comparison with… CONTINUE READING