Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose.

@article{AbdulGhani2006ContributionsOB,
  title={Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose.},
  author={Muhammad Abdul-Ghani and Devjit Tripathy and Ralph A DeFronzo},
  journal={Diabetes care},
  year={2006},
  volume={29 5},
  pages={
          1130-9
        }
}
Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are intermediate states in glucose metabolism that exist between normal glucose tolerance and overt diabetes. Epidemiological studies demonstrate that the two categories describe distinct populations with only partial overlap, suggesting that different metabolic abnormalities characterize IGT and IFG. Insulin resistance and impaired beta-cell function, the primary defects observed in type 2 diabetes, both can be detected in… CONTINUE READING
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