Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts.

@article{Gu2012ContributionsOA,
  title={Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts.},
  author={Aihua Gu and Guixiang Ji and Tao Jiang and Ailin Lu and Yongping You and Ning Liu and Chengzhang Luo and Wei Yan and Peng Zhao},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={128 2},
  pages={357-64}
}
The aryl hydrocarbon receptor (AHR) gene is involved in the response to polycyclic aromatic hydrocarbon (PAH) exposure. To investigate the hypothesis that the genetic variants in the AHR gene might be a causal genetic susceptibility to PAH-DNA adduct formation and glioma risk, we conducted a case-control study of 384 glioma cases and 384 cancer-free controls to explore the association between six common single-nucleotide polymorphisms of the AHR gene and glioma risk. Using PAH-DNA adducts as… CONTINUE READING
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