Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia.

@article{Yang2010ContributionsOT,
  title={Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia.},
  author={Lei Yang and Lin Jun Wang and Chun-Hong Zhao and Xiao-Juan Zhu and Yu Hou and Peng Jun and Ming Xiao Hou},
  journal={Blood},
  year={2010},
  volume={116 20},
  pages={
          4307-16
        }
}
Recent in vitro studies provide evidence for autoantibody-induced suppression of megakaryocytopoiesis and show a reduction in megakaryocyte production and maturation in the presence of immune thrombocytopenia (ITP) plasma. Here, we present CD34(+) cells from healthy umbilical cord blood mononuclear cells cultured in medium containing thrombopoietin, stem cell factor, interleukin-3, and 10% plasma from either ITP patients or healthy subjects. The quantity, quality, and apoptosis of… CONTINUE READING

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