Contributions of Subregions of the Prefrontal Cortex to Working Memory: Evidence from Brain Lesions in Humans

  title={Contributions of Subregions of the Prefrontal Cortex to Working Memory: Evidence from Brain Lesions in Humans},
  author={Notger G. Mller and Liana Machado and Robert T. Knight},
  journal={Journal of Cognitive Neuroscience},
We investigated working memory in patients with focal brain damage involving subregions of the prefrontal cortex (PFC). Lesions in the dorsal portion of lateral PFC or the ventromedial portion of orbital PFC did not impair performance in tasks that required maintenance and monitoring of object or spatial information. Larger lesions involving both ventral and dorsal parts of the lateral PFC impaired maintenance and monitoring of spatial and object information, with more severe deficits observed… CONTINUE READING

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