Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain

  title={Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain},
  author={M. Jarvis},
  journal={Expert Opinion on Therapeutic Targets},
  pages={513 - 522}
  • M. Jarvis
  • Published 2003
  • Medicine, Biology
  • Expert Opinion on Therapeutic Targets
  • ATP acts as a fast neurotransmitter by activating a family of ligand-gated ion channels, the P2X receptors. Functional homomeric (P2X3) and heteromeric (P2X2/3) receptors are highly localised on primary sensory afferent neurons that transmit nociceptive sensory information. Activation of these P2X3containing channels may provide a specific mechanism whereby ATP, released via synaptic transmission or by cellular injury, elicits pain. The physiological relevance of the pro-nociceptive actions of… CONTINUE READING
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