Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain

@article{Jarvis2003ContributionsOP,
  title={Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain},
  author={M. Jarvis},
  journal={Expert Opinion on Therapeutic Targets},
  year={2003},
  volume={7},
  pages={513 - 522}
}
  • M. Jarvis
  • Published 2003
  • Medicine, Biology
  • Expert Opinion on Therapeutic Targets
  • ATP acts as a fast neurotransmitter by activating a family of ligand-gated ion channels, the P2X receptors. Functional homomeric (P2X3) and heteromeric (P2X2/3) receptors are highly localised on primary sensory afferent neurons that transmit nociceptive sensory information. Activation of these P2X3containing channels may provide a specific mechanism whereby ATP, released via synaptic transmission or by cellular injury, elicits pain. The physiological relevance of the pro-nociceptive actions of… CONTINUE READING
    91 Citations
    P2X receptor ligands and pain
    • 15
    Painful Purinergic Receptors
    • 166
    • PDF
    Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors
    • 46
    P2X receptor antagonists for pain management: examination of binding and physicochemical properties
    • 65
    Pharmacology of P2X channels
    • 286
    • PDF
    Purinergic P2 receptors as targets for novel analgesics.
    • 196
    • PDF

    References

    SHOWING 1-10 OF 89 REFERENCES
    Inflammatory Mediators Potentiate ATP-gated Channels through the P2X3 Subunit*
    • 143
    • PDF
    P2X receptors and nociception.
    • 254
    • PDF
    ATP, P2X receptors and pain pathways.
    • 85
    Peripheral Inflammation Sensitizes P2X Receptor-Mediated Responses in Rat Dorsal Root Ganglion Neurons
    • 221
    • PDF
    Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X 3 receptors
    • 431
    • Highly Influential
    A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
    • 405
    • PDF
    Molecular physiology of P2X receptors.
    • 2,567
    • Highly Influential
    • PDF