Contributions of Kv3 channels to neuronal excitability.

  title={Contributions of Kv3 channels to neuronal excitability.},
  author={Bernardo Rudy and Alan Chow and Daniel C Lau and Yimy Amarillo and Andr{\'e}s Ozaita and Michael J Saganich and Herman Moreno and Marcela S. Nadal and Ricardo Hernandez-Pineda and Arturo Hern{\'a}ndez-Cruz and Alev Erisir and C. A. Leonard and Eleazar Vega-Saenz de Miera},
  journal={Annals of the New York Academy of Sciences},
Four mammalian Kv3 genes have been identified, each of which generates, by alternative splicing, multiple protein products differing in their C-terminal sequence. Products of the Kv3.1 and Kv3.2 genes express similar delayed-rectifier type currents in heterologous expression systems, while Kv3.3 and Kv3.4 proteins express A-type currents. All Kv3 currents activate relatively fast at voltages more positive than -10 mV, and deactivate very fast. The distribution of Kv3 mRNAs in the rodent CNS was… CONTINUE READING
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