Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy

@article{Kern2007ContributionsOI,
  title={Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy},
  author={Timothy S Kern},
  journal={Experimental Diabetes Research},
  year={2007},
  volume={2007},
  pages={602 - 607}
}
Diabetes causes metabolic and physiologic abnormalities in the retina, and these changes suggest a role for inflammation in the development of diabetic retinopathy. These changes include upregulation of iNOS, COX-2, ICAM-1, caspase 1, VEGF, and NF-kappaB, increased production of nitric oxide, prostaglandin E2, IL-1beta, and cytokines, as well as increased permeability and leukostasis. Using selective pharmacologic inhibitors or genetically modified animals, an increasing number of therapeutic… CONTINUE READING

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