Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila.

Abstract

The Drosophila kinesin-family protein Costal 2 (Cos2) and its mammalian ortholog Kif7 play dual roles in Hedgehog (Hh) signaling. In the absence of Hh, Cos2 and Kif7 contribute to proteolytic processing and silencing of the Hh-regulated transcription factors, Drosophila Cubitus interruptus (Ci) and mammalian Gli proteins. Cos2 and Kif7 are also necessary… (More)
DOI: 10.1242/dev.112904

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@article{Zadorozny2015ContributionsOC, title={Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila.}, author={Eva V. Zadorozny and Jamie C. Little and Daniel Kalderon}, journal={Development}, year={2015}, volume={142 5}, pages={931-42} }