Contributions of [Ca2+]i, [Pi]i, and pHi to altered diastolic myocyte tone during partial metabolic inhibition.

@article{Ikenouchi1991ContributionsO,
  title={Contributions of [Ca2+]i, [Pi]i, and pHi to altered diastolic myocyte tone during partial metabolic inhibition.},
  author={H Ikenouchi and Osami Kohmoto and M Katharine McMillan and William H. Barry},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={88 1},
  pages={55-61}
}
Ischemia may cause increased or decreased distensibility of the left ventricle, but the cellular mechanisms involved have not been clarified. We examined the possible contributions of changes in intracellular inorganic phosphate, pH, and Ca2+ concentrations to altered diastolic function in cultured myocytes subjected to partial metabolic inhibition. Paced cultured embryonic chick and adult rabbit ventricular myocytes superfused with 20 mM 2-deoxyglucose (2DG) exhibited an increase in end… CONTINUE READING

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