Contributions Lysophosphatidylcholine in Oxidized Low-Densit Lipoprotein Increases Endothelial Susceptibility to Polymorphonuclear Leukocyte-Induced Endothelial Dysfunction in Porcine Coronary Arteries Role of Protein Kinase C

@inproceedings{Sugiyama2005ContributionsLI,
  title={Contributions Lysophosphatidylcholine in Oxidized Low-Densit Lipoprotein Increases Endothelial Susceptibility to Polymorphonuclear Leukocyte-Induced Endothelial Dysfunction in Porcine Coronary Arteries Role of Protein Kinase C},
  author={Seigo Sugiyama and Kiyotaka Kugiyama and Masamichi Ohgushi and Kazuteru Fujimoto and Hirofumi Yasue},
  year={2005}
}
We have shown that transferred lysophosphatidylcholine (lysoPC) from oxidized low-density lipoprotein (OxLDL) to endothelial surface membrane activates protein kinase C (PKC) in endothelial cells, suggesting that Ox-LDL could alter endothelial functions through PKC activation. The purposes of the present study were to examine whether the endothelial susceptibility to polymorphonuclear leukocytes (PMNs) may be altered in Ox-LDL-treated coronary arteries, which have properties closely resembling… CONTINUE READING
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