Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis

Abstract

The integrin “very late antigen-4” (VLA-4) is expressed by numerous cells of hematopoietic origin and possesses a key function in the cellular immune response, e.g., by mediating leukocyte tethering, rolling, binding, and finally transmigration of the vascular wall at inflammatory sites. Thus, VLA-4 is a valuable target in medical sciences to interfere with… (More)
DOI: 10.1007/s10555-014-9545-x

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