Contribution of type I NOS to expired gas NO and bronchial responsiveness in mice.

@article{Sanctis1997ContributionOT,
  title={Contribution of type I NOS to expired gas NO and bronchial responsiveness in mice.},
  author={George T. De Sanctis and Sanjay Mehta and Lester Kobzik and C N Yandava and Aiping Jiao and Paul Lee Huang and Jeffrey M Drazen},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1997},
  volume={273 4},
  pages={L883-L888}
}
Nitric oxide (NO) can be measured in the expired gas of humans and animals, but the source of expired NO (FENO) and the functional contribution of the various known isoforms of NO synthase (NOS) to the NO measured in the expired air is not known. FENO was measured in the expired air of mice during mechanical ventilation via a tracheal cannula. FENO was significantly higher in wild-type B6SV129J +/+ mice than in mice with a targeted deletion of type I (neural) NOS (nNOS, -/-) (6.3 ± 0.9 vs. 3.9… CONTINUE READING

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