Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats.

@article{Bishop2009ContributionOT,
  title={Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats.},
  author={Christopher M. Bishop and David M Krolewski and Karen L. Eskow and Christopher J. Barnum and Kristin B. Dupre and Terrence Deak and Paul D. Walker},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 7},
  pages={1645-58}
}
Clinical and experimental studies implicate the use of serotonin (5-HT)1A receptor agonists for the reduction of L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID). Although raphe nuclei likely play a role in these antidyskinetic effects, an unexplored population of striatal 5-HT1A receptors (5-HT1AR) may also contribute. To better characterize this mechanism, L-DOPA-primed hemiparkinsonian rats received the 5-HT1AR agonist +/-8-OH-DPAT (0, 0.1, 1.0 mg/kg, i.p.) with or without… CONTINUE READING
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