Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans.

@article{Aratani2006ContributionOT,
  title={Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans.},
  author={Yasuaki Aratani and Fumiaki Kura and Haruo Watanabe and Hisayoshi Akagawa and Yukie Takano and Akiko Ishida-Okawara and Kazuo Suzuki and Nobuyo Maeda and Hideki Koyama},
  journal={Journal of medical microbiology},
  year={2006},
  volume={55 Pt 9},
  pages={
          1291-9
        }
}
The in vivo contribution of reactive oxygen species produced by neutrophils against Cryptococcus infection is not widely recognized. Myeloperoxidase (MPO) is a neutrophil-specific enzyme that catalyses the production of hypohalous acids such as HOCl from H2O2. This study investigated the role of MPO in immunological defence against Cryptococcus neoformans in an MPO-deficient (MPO-/-) mouse model. The survival of MPO-/- mice infected either intranasally or intravenously with C. neoformans was… 
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Results indicate that MPO promotes the development of lung neutrophilia and indirectly influences subsequent chemokine and cytokine production by other cell types in the lung.

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The knowledge pertaining to the biologic role of MPO and its downstream effects and mechanisms of action in health and disease is reviewed and discussed.

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A key role is established for SMS in the regulation of the killing activity of neutrophils against C. neoformans through a DAG-PKD dependent mechanism, and new insights are provided into the protective role of host sphingolipids against a fungal infection.

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...

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