Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditis.

@article{Nallapareddy2008ContributionOT,
  title={Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditis.},
  author={Sreedhar R. Nallapareddy and Kavindra V. Singh and Barbara E. Murray},
  journal={Infection and immunity},
  year={2008},
  volume={76 9},
  pages={4120-8}
}
Enterococcus faecium is a multidrug-resistant opportunist causing difficult-to-treat nosocomial infections, including endocarditis, but there are no reports experimentally demonstrating E. faecium virulence determinants. Our previous studies showed that some clinical E. faecium isolates produce a cell wall-anchored collagen adhesin, Acm, and that an isogenic acm deletion mutant of the endocarditis-derived strain TX0082 lost collagen adherence. In this study, we show with a rat endocarditis… CONTINUE READING