Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog.

@article{Blain2009ContributionOT,
  title={Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog.},
  author={Gr{\'e}gory M Blain and Curtis A. Smith and Kathleen S Henderson and Jerome A. Dempsey},
  journal={Journal of applied physiology},
  year={2009},
  volume={106 5},
  pages={1564-73}
}
We used extracorporeal perfusion of the reversibly isolated carotid sinus region to determine the effects of specific carotid body (CB) chemoreceptor inhibition on eupneic ventilation (Vi) in the resting, awake, intact dog. Four female spayed dogs were studied during wakefulness when CB was perfused with 1) normoxic, normocapnic blood; and 2) hyperoxic (>500 mmHg), hypocapnic ( approximately 20 mmHg) blood to maximally inhibit the CB tonic activity. We found that CB perfusion per se (normoxic… CONTINUE READING
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