Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2.

@article{Bravetti2009ContributionOT,
  title={Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2.},
  author={Anne-Lise Bravetti and St{\'e}phane Mesnage and Agn{\`e}s Lefort and Françoise Chau and C. H. J. Eckert and Louis Garry and Michel Arthur and Bruno Fantin},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 4},
  pages={1667-9}
}
The bactericidal activity of amoxicillin was investigated against Enterococcus faecalis JH2-2 and against an isogenic mutant deficient in the production of the N-acetylglucosaminidase AtlA. Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis.