Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy.

@article{Marwood2000ContributionOT,
  title={Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy.},
  author={R. D. Marwood and D. Jenkins and V. Corr{\^e}a and C. Taylor and B. Potter},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 22},
  pages={
          4278-87
        }
}
  • R. D. Marwood, D. Jenkins, +2 authors B. Potter
  • Published 2000
  • Chemistry, Medicine
  • Journal of medicinal chemistry
    • Syntheses of 3'-O-alpha-D-glucopyranosyl-1-beta-D-ribofuranosidoimidazole 2',3'', 4''-trisphosphate (7) and 3'-O-alpha-D-glucopyranosyl-9-beta-D-ribofuranosidopurine 2',3'',4''- trisphosphate (8), two analogues of the superpotent 1D-myo-inositol 1,4,5-trisphosphate receptor agonist adenophostin A (2), are described. 5-O-Benzyl-1, 2-O-isopropylidene-alpha-D-ribofuranose was prepared by an improved route from 1,2-O-isopropylidene-alpha-D-xylofuranose and was coupled with 3,4-di-O-acetyl-2,6-di-O… CONTINUE READING
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