Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD.

@article{Wall2001ContributionOT,
  title={Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD.},
  author={Susan M. Wall and Michael P Fischer and Pramod S. Mehta and Kathryn A. Hassell and Stanley J Park},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={280 5},
  pages={
          F913-21
        }
}
In rat kidney the "secretory" isoform of the Na+-K+-2Cl- cotransporter (NKCC1) localizes to the basolateral membrane of the alpha-intercalated cell. The purpose of this study was to determine whether rat outer medullary collecting duct (OMCD) secretes Cl- and whether transepithelial Cl- transport occurs, in part, through Cl- uptake across the basolateral membrane mediated by NKCC1 in series with Cl- efflux across the apical membrane. OMCD tubules from rats treated with deoxycorticosterone… CONTINUE READING
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