Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity

@inproceedings{Ho2017ContributionOT,
  title={Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity},
  author={Ivy A W Ho and Winston Shim},
  booktitle={BioMed research international},
  year={2017}
}
Glioblastoma is the most aggressive cancer of the brain. The dismal prognosis is largely attributed to the heterogeneous nature of the tumor, which in addition to intrinsic molecular and genetic changes is also influenced by the microenvironmental niche in which the glioma cells reside. The cancer stem cells (CSCs) hypothesis suggests that all cancers arise from CSCs that possess the ability to self-renew and initiate tumor formation. CSCs reside in specialized niches where interaction with the… CONTINUE READING

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