• DOI:10.1124/dmd.109.029546
Corpus ID: 17826299

Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes

@article{Rouguieg2010ContributionOT,
  title={Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes},
  author={Koukeb Rouguieg and N. Picard and F. Sauvage and J. Gaulier and P. Marquet},
  journal={Drug Metabolism and Disposition},
  year={2010},
  volume={38},
  pages={40 - 45}
}

• Koukeb Rouguieg, N. Picard, +2 authors P. Marquet
• Published 2010
• Chemistry, Medicine
• Drug Metabolism and Disposition

The goal of this study was to evaluate the specific contribution of individual UDP-glucuronosyltransferase (UGT) isoforms in the metabolism of buprenorphine (BUP) and norbuprenorphine (Nor-BUP), as well as the impact of their genetic variations. The glucuronidation of BUP and Nor-BUP was examined using human liver microsomes (HLMs) and heterologously expressed UGTs. The individual contribution of UGT isoforms was estimated using enzyme kinetic experiments combined with the relative activity… Expand

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