Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes

@article{Rouguieg2010ContributionOT,
  title={Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes},
  author={Koukeb Rouguieg and N. Picard and F. Sauvage and J. Gaulier and P. Marquet},
  journal={Drug Metabolism and Disposition},
  year={2010},
  volume={38},
  pages={40 - 45}
}
The goal of this study was to evaluate the specific contribution of individual UDP-glucuronosyltransferase (UGT) isoforms in the metabolism of buprenorphine (BUP) and norbuprenorphine (Nor-BUP), as well as the impact of their genetic variations. The glucuronidation of BUP and Nor-BUP was examined using human liver microsomes (HLMs) and heterologously expressed UGTs. The individual contribution of UGT isoforms was estimated using enzyme kinetic experiments combined with the relative activity… Expand
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References

SHOWING 1-10 OF 46 REFERENCES
Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.
  • 54
Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1.
  • 90
  • PDF
Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics.
  • 88
  • PDF
The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).
  • 311
  • Highly Influential
Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds.
  • 67
  • PDF
Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7.
  • Z. Cheng, G. Rios, +5 authors T. Tephly
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • 1998
  • 95
The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1.
  • 164
...
1
2
3
4
5
...