Contribution of the Argonaute-1 Isoforms to Invertebrate Antiviral Defense

@inproceedings{Huang2012ContributionOT,
  title={Contribution of the Argonaute-1 Isoforms to Invertebrate Antiviral Defense},
  author={Tianzhi Huang and Xiaobo Zhang},
  booktitle={PloS one},
  year={2012}
}
Argonaute (Ago) protein, the central component of the RNA interference (RNAi) pathway, plays important roles in host innate antiviral immunity. Most organisms harbor a large number of different Ago proteins and isoforms; however, the roles of Ago isoforms in immune defense against pathogens remain unclear. In the present study, three Argonaute-1 (Ago1) isoforms, termed Ago1A, Ago1B, and Ago1C, were found in Marsupenaeus japonicus shrimp. Quantitative real-time PCR (polymerase chain reaction… CONTINUE READING

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