Contribution of taxane biosynthetic pathway gene expression to observed variability in paclitaxel accumulation in Taxus suspension cultures.

@article{Patil2012ContributionOT,
  title={Contribution of taxane biosynthetic pathway gene expression to observed variability in paclitaxel accumulation in Taxus suspension cultures.},
  author={Rohan Anil Patil and Martin E. Kolewe and Jennifer Normanly and Elsbeth L Walker and Susan C. Roberts},
  journal={Biotechnology journal},
  year={2012},
  volume={7 3},
  pages={418-27}
}
Variability in product accumulation is one of the major obstacles limiting the widespread commercialization of plant cell culture technology to supply natural product pharmaceuticals. Despite extensive process engineering efforts, which have led to increased yields, plant cells exhibit variability in productivity that is poorly understood. Elicitation of Taxus cultures with methyl jasmonate (MeJA) induces paclitaxel accumulation, but to varying extents in different cultures. In the current… CONTINUE READING

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