Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ /Ca2+ exchange knockout mice.

@article{Torrente2017ContributionOS,
  title={Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ /Ca2+ exchange knockout mice.},
  author={Angelo Giovanni Torrente and Rui Zhang and Heidi Wang and Audrey Zaini and Brian J. Kim and Xin Yue and Kenneth D. Philipson and Joshua I. Goldhaber},
  journal={The Journal of physiology},
  year={2017},
  volume={595 12},
  pages={
          3847-3865
        }
}
KEY POINTS Repolarizing currents through K+ channels are essential for proper sinoatrial node (SAN) pacemaking, but the influence of intracellular Ca2+ on repolarization in the SAN is uncertain. We identified all three isoforms of Ca2+ -activated small conductance K+ (SK) channels in the murine SAN. SK channel blockade slows repolarization and subsequent depolarization of SAN cells. In the atrial-specific Na+ /Ca2+ exchanger (NCX) knockout mouse, cellular Ca2+ accumulation during spontaneous… CONTINUE READING