Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.

@article{Mancini1992ContributionOS,
  title={Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.},
  author={Donna M. Mancini and Gy{\"o}rgy Walter and Nathaniel Reichek and Robert E. Lenkinski and Kevin K McCully and James L. Mullen and John R. Wilson},
  journal={Circulation},
  year={1992},
  volume={85 4},
  pages={1364-73}
}
BACKGROUND The purpose of this study was to investigate the prevalence of skeletal muscle atrophy and its relation to exercise intolerance and abnormal muscle metabolism in patients with heart failure (HF). METHODS AND RESULTS Peak VO2, percent ideal body weight (% IBW), 24-hour urine creatinine (Cr), and anthropometrics were measured in 62 ambulatory patients with HF. 31P magnetic resonance spectroscopy (MRS) and imaging (MRI) of the calf were performed in 15 patients with HF and 10 control… CONTINUE READING
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