Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity.

@article{Kimman1992ContributionOS,
  title={Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity.},
  author={Tjeerd G. Kimman and Niels de Wind and N Oei-Lie and Joannes Maria Anthonis Pol and Anton J. M. Berns and Arno L. J. Gielkens},
  journal={The Journal of general virology},
  year={1992},
  volume={73 ( Pt 2)},
  pages={
          243-51
        }
}
Pigs (3 and 10 weeks old) were infected intranasally with Aujeszky's disease virus (ADV) mutants that functionally lacked one of the non-essential genes in the unique short region of the genome (except the gene encoding the 11K protein). Virus excretion in oropharyngeal fluid and disease symptoms were monitored. Some pigs were killed to study pathogenesis, whereas others were challenged with virulent ADV 8 weeks after the primary infection. Mutants lacking protein kinase, or glycoproteins gp63… CONTINUE READING

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