Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.

@article{Dai2004ContributionOS,
  title={Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.},
  author={Yi Dai and T OSHIHIRO O DA Fukuoka and Hu Wang and Hiroki Yamanaka and Koichi Obata and Atsushi Tokunaga and Koichi Noguchi},
  journal={Pain},
  year={2004},
  volume={108 3},
  pages={258-66}
}
The mechanism of mechanical hyperalgesia in inflammation might involve a 'mechanochemical' process whereby stretch evokes the release of adenosine 5'-triphosphate (ATP) from the damaged tissue that then excites nearby primary sensory nerve terminals. In the present study, phosphorylated extracellular signal-regulated protein kinase (pERK) immunoreactivity was used as a marker indicating functional activation of primary afferent neurons to examine the P2X receptor-mediated noxious response in… CONTINUE READING
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