Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

@article{Kamekura2006ContributionOR,
  title={Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.},
  author={Satoru Kamekura and Yosuke Kawasaki and Kazuto Hoshi and Takashi Shimoaka and Hirotaka Chikuda and Zenjiro Maruyama and Toshihisa Komori and Shingo Sato and Shu Takeda and Gerard Karsenty and Kozo Nakamura and Ung-il Chung and Hiroshi Kawaguchi},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 8},
  pages={2462-70}
}
OBJECTIVE By producing instability in mouse knee joints, we attempted to determine the involvement of runt-related transcription factor 2 (RUNX-2), which is required for chondrocyte hypertrophy, in the development of osteoarthritis (OA). METHODS An experimental mouse OA model was created by surgical transection of the medial collateral ligament and resection of the medial meniscus of the knee joints of heterozygous RUNX-2-deficient (Runx2+/-) mice and wild-type littermates. Cartilage… CONTINUE READING