Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart.

@article{Ghyselinck1998ContributionOR,
  title={Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart.},
  author={Norbert B. Ghyselinck and Olivia Wendling and Nadia Messaddeq and Andr{\'e}e Di{\'e}rich and Carmen Lampron and Didier D{\'e}cimo and St{\'e}phane Viville and Pierre Chambon and Manuel Mark},
  journal={Developmental biology},
  year={1998},
  volume={198 2},
  pages={303-18}
}
To investigate the relative contribution of retinoic acid receptor (RAR)beta isoforms in conotruncal septation, RAR beta 1 and beta 3 were inactivated in the mouse. Mice lacking RAR beta 1 and beta 3 appear normal. Disruption of these isoforms in RAR alpha or RAR gamma null genetic backgrounds results in a high postpartum lethality. However, except for ocular defects found in RAR beta 1-3/RAR gamma compound mutants, the double null mutants display only abnormalities seen in single null mutants… CONTINUE READING
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