Contribution of reduced mitral regurgitant volume to vasodilator effect in severe left ventricular failure secondary to coronary artery disease or idiopathic dilated cardiomyopathy.

@article{Weiland1986ContributionOR,
  title={Contribution of reduced mitral regurgitant volume to vasodilator effect in severe left ventricular failure secondary to coronary artery disease or idiopathic dilated cardiomyopathy.},
  author={D S Weiland and Marvin A. Konstam and Deeb N. Salem and Thomas R. Martin and Steven Roy Cohen and Michael R. Zile and D Das},
  journal={The American journal of cardiology},
  year={1986},
  volume={58 10},
  pages={1046-50}
}
Although vasodilators improve cardiac output in severe left ventricular (LV) failure, the degree to which reduction in mitral regurgitation (MR) contributes to this response is unknown. In the present study, nitroprusside-induced changes in forward cardiac output were compared with simultaneous radionuclide LV output in 14 patients with severe LV systolic dysfunction in the absence of known primary valvular disease. Regurgitant output was estimated as LV output minus forward output and… CONTINUE READING