Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections.

@article{Rumbaugh1999ContributionOQ,
  title={Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections.},
  author={Kendra P. Rumbaugh and John A. Griswold and Barbara H. Iglewski and Abdul N Hamood},
  journal={Infection and immunity},
  year={1999},
  volume={67 11},
  pages={5854-62}
}
The Pseudomonas aeruginosa quorum-sensing systems, las and rhl, control the production of numerous virulence factors. In this study, we have used the burned-mouse model to examine the contribution of quorum-sensing systems to the pathogenesis of P. aeruginosa infections in burn wounds. Different quorum-sensing mutants of P. aeruginosa PAO1 that were defective in the lasR, lasI, or rhlI gene or both the lasI and rhlI genes were utilized. The following parameters of the P. aeruginosa infection… CONTINUE READING