Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis.

  title={Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis.},
  author={D G Jo and J W Chang and H Hong and Inhee Mook-jung and Yong-Keun Jung},
  journal={Biochemical and biophysical research communications},
  volume={305 1},
Mutant presenilins cause early-onset of familial Alzheimer's disease and render cells vulnerable to apoptosis. Calsenilin/DREAM/KChIP3 is a multifunctional calcium-binding protein that interacts with presenilin and mediates calcium-mediated apoptosis. In the present study, we report that the calsenilin-mediated apoptosis is regulated by presenilin. The… CONTINUE READING