Contribution of polyol pathway to diabetes-induced oxidative stress.

@article{Chung2003ContributionOP,
  title={Contribution of polyol pathway to diabetes-induced oxidative stress.},
  author={Stephen S. M. Chung and E. C. Ho and K. Lam and Sookja K. Chung},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 8 Suppl 3},
  pages={
          S233-6
        }
}
Diabetes causes increased oxidative stress, which is thought to play an important role in the pathogenesis of various diabetic complications. However, the source of the hyperglycemia-induced oxidative stress is not clear. It was found that the polyol pathway is the major contributor to oxidative stress in the lenses and nerves of diabetic mice. The first enzyme in the pathway, aldose reductase (AR), reduces glucose to sorbitol, which is then converted to fructose by sorbitol dehydrogenase (SDH… Expand
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