Contribution of pneumolysin and autolysin to the pathogenesis of experimental pneumococcal endophthalmitis.

@article{Ng2002ContributionOP,
  title={Contribution of pneumolysin and autolysin to the pathogenesis of experimental pneumococcal endophthalmitis.},
  author={Eugene W. M. Ng and J Ricardo Costa and Nasrollah Samiy and Kathryn L. Ruoff and Edward A Connolly and Felecia V Cousins and Donald J. D'amico},
  journal={Retina},
  year={2002},
  volume={22 5},
  pages={
          622-32
        }
}
PURPOSE To determine the contribution of pneumolysin and autolysin, two putative pneumococcal virulence proteins, to the pathogenesis of Streptococcus pneumoniae endophthalmitis. METHODS Endophthalmitis was established in Lewis rats by intravitreal injection of pneumococcal strains at an inoculum of 10 organisms. The virulence of three closely related type 2 S. pneumoniae strains were compared: a pneumolysin-deficient derivative (PLN-A), an autolysin-deficient derivative (AL-6), and their… CONTINUE READING
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