Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis.


BACKGROUND von Willebrand factor (VWF) is a glycoprotein that plays an important role in primary hemostasis. VWF is synthesized and stored in endothelial cells (ECs) and megakaryocytes/platelets. Plasma VWF is primarily derived from ECs and is generally believed to be essential for hemostasis. VWF synthesized in megakaryocytes is stored in platelet… (More)
DOI: 10.1111/j.1538-7836.2012.04797.x


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