Contribution of phospholipases A2 and D to arachidonic acid liberation and prostaglandin D2 formation with increase in intracellular Ca2+ concentration in rat peritoneal mast cells.

@article{Ishimoto1994ContributionOP,
  title={Contribution of phospholipases A2 and D to arachidonic acid liberation and prostaglandin D2 formation with increase in intracellular Ca2+ concentration in rat peritoneal mast cells.},
  author={Takayuki Ishimoto and Satoshi Akiba and Takashige Sato and Toshihiro Fujii},
  journal={European journal of biochemistry},
  year={1994},
  volume={219 1-2},
  pages={401-6}
}
The contribution of phospholipases A2 (PLA2) and D (PLD) activation to arachidonic acid liberation and prostaglandin D2 (PGD2) formation was studied in stimulated rat peritoneal mast cells. Stimulation of the cells with ionomycin induced time-dependent and Ca(2+)-concentration-dependent increase in arachidonic acid liberation and PGD2 formation, and the Ca(2+)-dependent increase was especially remarkable at extracellular Ca2+ concentration higher than 200 microM. Staurosporine did not induce… CONTINUE READING

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…