Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration

  title={Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration},
  author={R. Klimas and Diana Witticke and Sarah El Fallah and G. Mikus},
  journal={Expert Opinion on Drug Metabolism & Toxicology},
  pages={517 - 528}
  • R. Klimas, Diana Witticke, +1 author G. Mikus
  • Published 2013
  • Chemistry, Medicine
  • Expert Opinion on Drug Metabolism & Toxicology
  • Objective: Oxycodone (OC) is an opioid which exerts its analgesic effect through µ-receptors in the brain. It is metabolized through CYP450 enzymes and some of the metabolites show pharmacological activity. The aim of this investigation is to research the contribution of the metabolites of OC to its overall analgesic effect. A further aim was to elucidate the role of drug–drug interactions and CYP2D6 polymorphism. Research design and methods: The authors performed a literature search to… CONTINUE READING
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