Contribution of oxidative stress to pulmonary arterial hypertension.

  title={Contribution of oxidative stress to pulmonary arterial hypertension.},
  author={Vincent G DeMarco and Adam T. Whaley-Connell and James R. Sowers and Javad Habibi and Kevin C. Dellsperger},
  journal={World journal of cardiology},
  volume={2 10},
Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene… CONTINUE READING