Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment.

@article{Simplicio2015ContributionOO,
  title={Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment.},
  author={Janaina A. Simplicio and Leonardo B. M. Resstel and Daniela Pretti da Cunha Tirapelli and Pedro D'Orl{\'e}ans-Juste and Carlos Renato Tirapelli},
  journal={Vascular pharmacology},
  year={2015},
  volume={73},
  pages={
          124-37
        }
}
OBJECTIVES The effects of chronic fluoxetine treatment were investigated on blood pressure and on vascular reactivity in the isolated rat aorta. METHODS AND RESULTS Male Wistar rats were treated with fluoxetine (10 mg/kg/day) for 21 days. Fluoxetine increased systolic blood pressure. Chronic, but not acute, fluoxetine treatment increased the contractile response induced by phenylephrine, serotonin (5-HT) and KCl in endothelium-intact rat aortas. L-NAME and ODQ did not alter the contraction… CONTINUE READING

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