Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes.

@article{Kouzuki1999ContributionOO,
  title={Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes.},
  author={Hirokazu Kouzuki and Hiroshi Suzuki and Kousei Ito and Rikiya Ohashi and Yuichi Sugiyama},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={288 2},
  pages={627-34}
}
Organic anion transporting polypeptide (oatp1) has been cloned from rat liver as one of the transporters responsible for the hepatic uptake of ligands, and its substrate specificity has been determined. However, the contribution of oatp1 to the Na+-independent uptake of ligands into rat hepatocytes remains to be investigated. In the present study, we determined the contribution of oatp1 and examined the uptake of ligands into primary cultured hepatocytes (cultured for 4 h) and into COS-7 cells… CONTINUE READING

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