Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection.

@article{Mallal2000ContributionON,
  title={Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection.},
  author={Simon A Mallal and M. O. John and Corey B Moore and Ian R. James and Elizabeth Mckinnon},
  journal={AIDS},
  year={2000},
  volume={14 10},
  pages={1309-16}
}
BACKGROUND Progressive subcutaneous fat wasting, fat accumulation, dyslipidaemia and insulin resistance in HIV-infected patients on antiretroviral therapy has been attributed to the long-term toxicity of HIV protease inhibitors (PI). More recently, fat wasting has been observed in patients who have never taken a PI, implicating an independent effect of nucleoside analogue reverse transcriptase inhibitor (NRTI) therapy. OBJECTIVES To determine the relative contribution of NRTI and PI, as well… CONTINUE READING