Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae.

@article{Rosenow1997ContributionON,
  title={Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae.},
  author={Carsten Rosenow and Patrick Ryan and Jeffrey N Weiser and Sandra J Johnson and Patricia A. Font{\'a}n and Ake Ortqvist and H R Masure},
  journal={Molecular microbiology},
  year={1997},
  volume={25 5},
  pages={819-29}
}
The surface of Streptococcus pneumoniae is decorated with a family of choline-binding proteins (CBPs) that are non-covalently bound to the phosphorylcholine of the teichoic acid. Two examples (PspA, a protective antigen, and LytA, the major autolysin) have been well characterized. We identified additional CPBs and characterized a new CBP, CbpA, as an adhesin and a determinant of virulence. Using choline immobilized on a solid matrix, a mixture of proteins from a pspA-deficient strain of… CONTINUE READING
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