Contribution of non-endothelium-dependent substances to exercise hyperaemia: are they O(2) dependent?

@article{Marshall2012ContributionON,
  title={Contribution of non-endothelium-dependent substances to exercise hyperaemia: are they O(2) dependent?},
  author={Janice M Marshall and Clare J Ray},
  journal={The Journal of physiology},
  year={2012},
  volume={590 24},
  pages={
          6307-20
        }
}
This review considers the contributions to exercise hyperaemia of substances released into the interstitial fluid, with emphasis on whether they are endothelium dependent or O(2) dependent. The early phase of exercise hyperaemia is attributable to K(+) released from contracting muscle fibres and acting extraluminally on arterioles. Hyperpolarization of vascular smooth muscle and endothelial cells induced by K(+) may also facilitate the maintained phase, for example by facilitating conduction of… CONTINUE READING

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