Contribution of nitric oxide to the endothelium-dependent hyperpolarization in rat aorta.

@article{Vanheel1994ContributionON,
  title={Contribution of nitric oxide to the endothelium-dependent hyperpolarization in rat aorta.},
  author={Bert Vanheel and Johan van de Voorde and Isidoor Leusen},
  journal={The Journal of physiology},
  year={1994},
  volume={475 2},
  pages={
          277-84
        }
}
1. The effect of endogenous and exogenous nitric oxide on the membrane potential (Em) of smooth muscle cells of the thoracic aorta of rats was investigated. 2. In tissues with intact endothelium, application of ACh or carbachol generated a change of the membrane potential consisting of an initial hyperpolarization by 10-12 mV, followed by a partial recovery toward a level which was at 10 min still 6-8 mV more negative than in control conditions. 3. Application of NG-nitro-L-arginine methylester… CONTINUE READING

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