Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus.

@article{Chuang2009ContributionON,
  title={Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus.},
  author={Yao-Chung Chuang and Shang-Der Chen and C T Liou and Tsu-Kung Lin and Wen-Neng Chang and Samuel H. H. Chan and Alice Y. W. Chang},
  journal={Epilepsia},
  year={2009},
  volume={50 4},
  pages={731-46}
}
PURPOSE One cellular consequence of status epilepticus is apoptosis in the hippocampal CA3 subfield. We evaluated the hypothesis that the repertoire of cellular events that underlie such elicited cell death entails mitochondrial dysfunction induced by an excessive production of nitric oxide synthase II (NOS II)-derived NO, increased superoxide anion (O(2)(-)) production, and peroxynitrite formation. METHODS In Sprague-Dawley rats, kainic acid was microinjected unilaterally into the… CONTINUE READING
20 Citations
50 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…